RAF Typhoon FGR4s have conducted a mission with France's air force in a joint strike against an subterranean weapons facility in Syria employed by the Daesh militant organization, as stated by the UK's MoD.
The facility, identified by intelligence, was believed to be containing munitions and bombs, the statement said, and was situated in hills just north of Palmyra in the heart of Syria.
"Our aircraft utilized Paveway IV guided bombs to target a series of approach shafts leading to the site... early reports are that the target was engaged successfully," the MoD said.
There was no sign of any civilian casualties in the attack conducted Saturday night and every plane involved returned to base without incident, the ministry further stated.
The British jets were assisted by a Voyager tanker plane.
The Islamic State group - referred to as the so-called Islamic State - established militant control over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates the UK's leading role, and determination to stand shoulder to shoulder with allied nations, to eliminate any revival of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the Defence Secretary said.
UK warplanes have conducted patrols over Syria to "prevent any attempted resurgence" of IS after its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank every member of our armed forces participating in this strike for their expertise and their courage," the Defence Secretary added. "Including them were a great many British personnel on duty over the holidays. This action, to eliminate militants who threaten our way of life, demonstrates how British military are always on standby, throughout the year, ensuring Britain's security at home and influential overseas."
During December, the US military conducted what it described as a "massive strike" against Daesh sites in Syria, subsequent to an assault killed two US troops and a civilian interpreter in Palmyra.
The UN reports Islamic State still has between 5,000 and 7,000 combatants in Iraq and Syria.